Error-prone repair DNA polymerases in prokaryotes and eukaryotes.

@article{Goodman2002ErrorproneRD,
  title={Error-prone repair DNA polymerases in prokaryotes and eukaryotes.},
  author={Myron F. Goodman},
  journal={Annual review of biochemistry},
  year={2002},
  volume={71},
  pages={
          17-50
        }
}
  • M. Goodman
  • Published 2002
  • Biology, Medicine
  • Annual review of biochemistry
DNA repair is crucial to the well-being of all organisms from unicellular life forms to humans. A rich tapestry of mechanistic studies on DNA repair has emerged thanks to the recent discovery of Y-family DNA polymerases. Many Y-family members carry out aberrant DNA synthesis-poor replication accuracy, the favored formation of non-Watson-Crick base pairs, efficient mismatch extension, and most importantly, an ability to replicate through DNA damage. This review is devoted primarily to a… 
Damage repair DNA polymerases Y.
  • Wei Yang
  • Biology, Medicine
    Current opinion in structural biology
  • 2003
TLDR
Although devoid of a 3'-->5' exonuclease activity, the Y-family polymerases possess a unique "little finger" domain that facilitates DNA association, catalytic efficiency and interactions with auxiliary factors.
Functions of eukaryotic DNA polymerases.
TLDR
The list of DNA template-dependent eukaryotic DNA polymerases now consists of 14 enzymes with amazingly different properties, and the possible functions of these polymerases in DNA damage repair, the replication of intact and damaged chromosomes, and cell cycle checkpoints are discussed.
Visualizing mutagenic repair: novel insights into bacterial translesion synthesis
TLDR
The current status of research on bacterial TLS is discussed, with emphasis on recent insights gained mostly through microscopy at the single-cell and single-molecule level.
Translesion synthesis DNA polymerases and control of genome stability.
TLDR
The properties of prokaryotic and eukaryotic TLS polymerases and their roles in modulating the rate of spontaneous and genotoxicant-induced mutations are discussed and recent insights into the molecular mechanisms regulating the participation of error-prone TLS polymerase in the genome replication are reviewed.
Translesion DNA polymerases.
TLDR
Despite being tightly regulated by a variety of transcriptional and posttranslational controls, the low-fidelity TLS polymerases also gain access to undamaged DNA where their inaccurate synthesis may actually be beneficial for genetic diversity and evolutionary fitness.
Characterization of Escherichia coli translesion synthesis polymerases and their accessory factors.
TLDR
This chapter outlines procedures for in vivo and in vitro analysis of the E. coli Y family polymerases and their accessory factors, and several regulatory factors, including those encoded by the umuD gene that influence the activity of UmuC.
Specialised DNA polymerases in Escherichia coli: roles within multiple pathways
TLDR
Evidence is re-visited that TLS polymerases could participate in nucleotide excision repair, homologous recombination and transcription, and oxidation of the nucleotide pool, which is known to be induced by multiple stressors, appears to favour TLS polymerase activity and thus increases mutation rates.
Eukaryotic DNA Polymerases
TLDR
This work has shown that DNA polymerases can have tissue-specific functions in lymphoid cells, where they contribute to somatic hypermutation of immunoglobulin genes and to human disease, as well as investigating their role in chromosome replication and its role in genome stability.
Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance
TLDR
The current state of knowledge about the eukaryotic DNA damage tolerance pathway translesion synthesis (TLS), a process in which specialized DNA polymerases replicate across from DNA lesions, is summarized.
Post-replication repair in DT40 cells: translesion polymerases versus recombinases.
TLDR
This article has taken advantage of the chicken cell line DT40 to perform a genetic analysis of translesion synthesis and homologous recombination and to characterize genetic interactions between these two pathways in vertebrates.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 357 REFERENCES
Managing DNA polymerases: Coordinating DNA replication, DNA repair, and DNA recombination
  • M. Sutton, G. Walker
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2001
TLDR
Here, the current understanding of the regulation of action of DNA polymerases with respect to their roles in DNA replication, TLS, DNA repair, DNA recombination, and cell cycle progression is summarized.
Low fidelity DNA synthesis by human DNA polymerase-η
TLDR
It is shown that human pol-η copies undamaged DNA with much lower fidelity than any other template-dependent DNA polymerase studied, indicating a relaxed requirement for correct base pairing geometry and indicates that the function of pol- η may be tightly controlled to prevent potentially mutagenic DNA synthesis.
Mutation induced by DNA damage: a many protein affair.
TLDR
This brief review of the mechanisms responsible for the replication skills of the polymerase and the sources of occasional failure are considered, with an emphasis on the SOS response induced by a replication-blocking lesion.
Fidelity and Processivity of Saccharomyces cerevisiae DNA Polymerase η*
TLDR
It is suggested that pol η's low fidelity reflects a flexibility in its active site rendering it more tolerant of DNA damage, while its low processivity limits its activity to reduce errors.
Recombinational DNA repair of damaged replication forks in Escherichia coli: questions.
  • M. Cox
  • Biology, Medicine
    Annual review of genetics
  • 2001
TLDR
This review focuses on several key gaps in understanding on the levels and types of DNA damage present as a function of growth conditions and the enzymology of some of the key reactions required for repair.
Mutagenesis in eukaryotes dependent on DNA polymerase zeta and Rev1p.
  • C. Lawrence, V. Maher
  • Biology, Medicine
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 2001
TLDR
It is suggested that Pol zeta is best regarded as a replication enzyme, albeit one that is used only intermittently, that promotes extension at forks the progress of which is blocked for any reason, whether the presence of an unedited terminal mismatch or unrepaired DNA lesion.
Mismatch Extension Ability of Yeast and Human DNA Polymerase η*
TLDR
It is found that both yeast and human Polη extend from mismatched base pairs with a frequency of ∼10− 3 relative to matched base pairs, which is expected to be more accurate than that predicted from the fidelity of nucleotide incorporation alone.
Recombinational Repair of DNA Damage inEscherichia coli and Bacteriophage λ
  • A. Kuzminov
  • Biology
    Microbiology and Molecular Biology Reviews
  • 1999
TLDR
It is now appreciated that DNA repair and homologous recombination are related through DNA replication, and knowledge about recombinational repair in the broader context of DNA replication will guide future experimentation.
Fidelity and Processivity of DNA Synthesis by DNA Polymerase κ, the Product of the Human DINB1 Gene*
TLDR
The very low fidelity and moderate processivity of pol κ is novel in comparison to any previously studied DNA polymerase, and is consistent with a role in spontaneous mutagenesis.
Disruption of mouse polymerase ζ (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro
TLDR
MRev3 could be required to repair a form of externally induced DNA damage that otherwise accumulates during clonal expansion or, consistent with the high homology shared between its Rev7 partner and the mitotic checkpoint gene product Mad2, mRev3 might play a role in cell proliferation and genomic stability even in the absence of environmentally induced damage.
...
1
2
3
4
5
...