Erratum: OncoScore: a novel, Internet-based tool to assess the oncogenic potential of genes

@article{Piazza2017ErratumOA,
  title={Erratum: OncoScore: a novel, Internet-based tool to assess the oncogenic potential of genes},
  author={Rocco Piazza and Daniele Ramazzotti and Roberta Spinelli and Alessandra Pirola and Luca De Sano and Pierangelo Ferrari and Vera Magistroni and Nicoletta Cordani and Nitesh D. Sharma and Carlo B Gambacorti-Passerini},
  journal={Scientific Reports},
  year={2017},
  volume={7}
}
This corrects the article DOI: 10.1038/srep46290. 
8 Citations

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References

SHOWING 1-10 OF 36 REFERENCES

MiR200c targets IRS1 and suppresses prostate cancer cell growth

TLDR
It is shown that miR 200c is a posttranscriptional regulator of insulin receptor substrate 1 (IRS1) and over‐expression of miR200c suppresses prostate cancer cell growth.

RBM5 as a putative tumor suppressor gene for lung cancer.

  • L. SutherlandKe WangA. Robinson
  • Biology
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • 2010
TLDR
To more thoroughly assess the potential involvement of RBM5 as a lung cancer regulatory protein, more research is required regarding (a) the expression of not only full-length R BM5 but all of the alternate variants associated with the locus, in relation to histologic subtype and smoking history, and (b) the mutation status of various genes within the transforming growth factor-alpha signaling pathway.

GeneRanker: An Online System for Predicting Gene-Disease Associations for Translational Research

TLDR
GeneRanker is an online system that allows researchers to obtain a ranked list of genes potentially related to a specific disease or biological process by combining gene-disease associations with protein-protein interactions extracted from the literature, using computational analysis of the protein network topology to more accurately rank the predicted associations.

Targeting CDC25C, PLK1 and CHEK1 to overcome Docetaxel resistance induced by loss of LZTS1 in prostate cancer

TLDR
The findings identify an important role of LZTS1 through its regulation ofCDC25C in Docetaxel resistance in prostate cancer and suggest that CDC25C, or the mitotic kinases CHEK1 and PLK1, could be efficient therapeutic targets to overcome Docetxel resistance.

mRNA expression of the putative antimetastatic gene BRMS1 and of apoptosis-related genes in breast cancer.

TLDR
The results point towards a possible link between BRMS1 expression and apoptosis in human breast cancer through a relationship with the expression of genes belonging to the X-chromosome RBM family.

Fusion of NUP98 and the SET binding protein 1 (SETBP1) gene in a paediatric acute T cell lymphoblastic leukaemia with t(11;18)(p15;q12)

TLDR
Fluorescent in situ hybridisation showed NUP98 and SET binding protein 1(SETBP1) fusion signals; other analyses showed that exon 12 of N UP98 was fused in‐frame with exon 5 of SETBP1, suggesting that NUP 98/SETBP 1 transcript is pathogenetically important.

Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia

TLDR
JMML was characterized by a paucity of gene mutations with somatic or germline RAS pathway involvement in 82 cases, and the SETBP1 and JAK3 genes were among common targets for secondary mutations.

Deletion, methylation, and expression of the NKX3.1 suppressor gene in primary human prostate cancer.

TLDR
Even in the presence of allelic loss, NKX3.1 expression is reduced over a wide range in prostate cancer at the time of prostatectomy, suggesting that diverse factors influence expression.

Characterization of the Genomic Architecture and Mutational Spectrum of a Small Cell Prostate Carcinoma

TLDR
A variety of methods were used to analyze and interpret the tumor genome for copy number variation, loss of heterozygosity (LOH), somatic mosaicism and mutations in genes from known cancer pathways.

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

TLDR
The ANNOVAR tool to annotate single nucleotide variants and insertions/deletions, such as examining their functional consequence on genes, inferring cytogenetic bands, reporting functional importance scores, finding variants in conserved regions, or identifying variants reported in the 1000 Genomes Project and dbSNP is developed.