Ero1-Lα plays a key role in a HIF-1-mediated pathway to improve disulfide bond formation and VEGF secretion under hypoxia: implication for cancer

@article{May2005Ero1LPA,
  title={Ero1-Lα plays a key role in a HIF-1-mediated pathway to improve disulfide bond formation and VEGF secretion under hypoxia: implication for cancer},
  author={Dalit May and Ahuva Itin and Oded Gal and Hagar Kalinski and Elena Feinstein and E. Keshet},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={1011-1020}
}
Oxygen is the ultimate source of oxidizing power for disulfide bond formation, suggesting that under limiting oxygen proper protein folding might be compromised. We show that secretion of vascular endothelial growth factor (VEGF), a protein with multiple disulfide bonds, was indeed impeded under hypoxia and was partially restored by artificial increase of oxidizing equivalents with diamide. Physiologically, the oxireductase endoplasmic reticulum oxidoreductin-1 (Ero1)-Lα, but not other proteins… CONTINUE READING