Ernest Duchesne and the concept of fungal antibiotic therapy

  title={Ernest Duchesne and the concept of fungal antibiotic therapy},
  author={Serge Duckett},
  journal={The Lancet},
  • S. Duckett
  • Published 11 December 1999
  • Medicine
  • The Lancet
History of Antibiotics Research.
The situation within the pre-antibiotic era as well as in the early antibiotic era will be described until the Golden Age of Antibiotics will conclude this time travel.
Antibiotic resistance and virulence: Understanding the link and its consequences for prophylaxis and therapy
Alternative approaches, such as preventive and therapeutic anti‐bacterial immunotherapies that have the potential to by‐pass the classic antibiotics are reviewed.
Antimicrobials, chemotherapeutics or antibiotics?
There is a need for stability and consistency within Science, this must also be applied to the business of defining the different categories of antimicrobials correctly, since various compounds known for activities outside this field of interest are now also surfacing as antimicroBials.
Escherichia coli and Serratia fonticola ESBLs as a potential source of antibiotics resistance dissemination in the Tricity water reservoirs.
The presence of highly diverse ESBL strains with multiple drug resistance patterns in the Tricity water reservoirs could possibly pose a threat to human health and create a suitable ground for acquiring antibiotics resistance in the natural environment.
Antibacterial activity and mechanism of action of lipophilic antioxidants.
The potent and selective antibacterial activity, and low resistance potential upon extended subculture, suggest that these compounds could be used topically in combination with gentamicin to treat infected wounds.
Natural products as inhibitors of bacterial type IV secretion systems
Evidence is provided that plant-based treatments may target T4SS which are the delivery systems of virulence factors of certain pathogens, such as H. pylori, as well as co-adjuvants of antibacterial compounds to inhibit the acquisition of resistance genes by the pathogens from commensal non-pathogenic bacteria.
The silver cation (Ag+): antibacterial mode of action and mechanisms of resistance
Detailed characterisation of a known Ag+-resistance determinant was conducted to provide further insights into the mechanism of Ag+ resistance conferred by this determinant, which could potentially be applied to optimising the future uses of Ag+, as an antibacterial agent.


Alexander Fleming: The Man and the Myth
The story of penicillin has become the story of Alexander Fleming: world opinion has conferred upon him sole credit for what is arguably the single most important medical discovery ever made. Gwyn
DNA-damaging activity of patulin in Escherichia coli
At a concentration of 10 micrograms/ml, patulin caused single-strand DNA breaks in living cells of Escherichia coli. At 50 micrograms/ml, double-strand breaks were observed also. Single-strand breaks
An Index-Catalogue
THE regularity with which the large annual volumes of this great work reach us is most reassuring, and now its completion in some six more years may be looked upon as practically certain, considering
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