Erm/thyroid transcription factor 1 interactions modulate surfactant protein C transcription.

@article{Lin2006ErmthyroidTF,
  title={Erm/thyroid transcription factor 1 interactions modulate surfactant protein C transcription.},
  author={Sui Lin and Anne Karina Perl and John M. Shannon},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 24},
  pages={16716-26}
}
Expression of surfactant protein C (SP-C), which is restricted to alveolar type II epithelial cells of the adult lung, is critically dependent on thyroid transcription factor 1 (TTF-1). In the present study we have demonstrated that Erm, a member of the Ets family of transcription factors, is expressed in the distal lung epithelium during development and is also restricted to alveolar type II cells in the adult. Erm was up-regulated by fibroblast growth factors (FGFs) in culture, and blocking… CONTINUE READING

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