Erlotinib attenuates homologous recombinational repair of chromosomal breaks in human breast cancer cells.

@article{Li2008ErlotinibAH,
  title={Erlotinib attenuates homologous recombinational repair of chromosomal breaks in human breast cancer cells.},
  author={Li-ping Li and Hong Wang and Eddy Shih-Hsin Yang and Carlos L. Arteaga and Fen Xia},
  journal={Cancer research},
  year={2008},
  volume={68 22},
  pages={9141-6}
}
The epidermal growth factor receptor (EGFR) family has been implicated in several cancers, including breast, and its members have become the target of novel cancer therapies. In this report, we show a novel link between erlotinib, a potent EGFR inhibitor, DNA damage, and homology-directed recombinational repair (HDR) in human breast cancer cells. Erlotinib suppresses HDR. This is not secondary to erlotinib-mediated changes in cell cycle and is associated with increased gamma-H2AX foci, which is… CONTINUE READING
57 Citations
17 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 57 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 17 references

Similar Papers

Loading similar papers…