Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2.

@article{EsparsOgando2002Erk5PI,
  title={Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2.},
  author={Azucena Espar{\'i}s-Ogando and Elena D{\'i}az-Rodr{\'i}guez and Juan Carlos Montero and Laura Yuste and Piero Crespo and Atanasio Pandiella},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 1},
  pages={
          270-85
        }
}
The four receptor tyrosine kinases of the ErbB family play essential roles in several physiological processes and have also been implicated in tumor generation and/or progression. Activation of ErbB1/EGFR is mainly triggered by epidermal growth factor (EGF) and other related ligands, while activation of ErbB2, ErbB3, and ErbB4 receptors occurs by binding to another set of EGF-like ligands termed neuregulins (NRGs). Here we show that the Erk5 mitogen-activated protein kinase (MAPK) pathway… CONTINUE READING

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