Erk regulation of actin capping and bundling by Eps8 promotes cortex tension and leader bleb-based migration

  title={Erk regulation of actin capping and bundling by Eps8 promotes cortex tension and leader bleb-based migration},
  author={Jeremy S. Logue and Alexander X Cartagena-Rivera and Michelle A. Baird and Michael W. Davidson and Richard S. Chadwick and Clare M. Waterman and Pekka Lappalainen},
Within the confines of tissues, cancer cells can use blebs to migrate. Eps8 is an actin bundling and capping protein whose capping activity is inhibited by Erk, a key MAP kinase that is activated by oncogenic signaling. We tested the hypothesis that Eps8 acts as an Erk effector to modulate actin cortex mechanics and thereby mediate bleb-based migration of cancer cells. Cells confined in a non-adhesive environment migrate in the direction of a very large 'leader bleb.' Eps8 bundling activity… CONTINUE READING
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