Erk is essential for growth, differentiation, integrin expression, and cell function in human osteoblastic cells.

@article{Lai2001ErkIE,
  title={Erk is essential for growth, differentiation, integrin expression, and cell function in human osteoblastic cells.},
  author={C F Lai and Lilamber Chaudhary and Alfonso Fausto and Linda R. Halstead and Daniel S Ory and Louis V. Avioli and S. L. Cheng},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 17},
  pages={14443-50}
}
Extracellular signal-regulated kinases (Erks), members of the mitogen-activated protein kinase superfamily, play an important role in cell proliferation and differentiation. In this study we employed a dominant negative approach to determine the role of Erks in the regulation of human osteoblastic cell function. Human osteoblastic cells were transduced with a pseudotyped retrovirus encoding either a mutated Erk1 protein with a dominant negative action against both Erk1 and Erk2 (Erk1DN cells… CONTINUE READING

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