Erk and PI-3 kinase are necessary for collagen binding and actin reorganization in corneal epithelia.

@article{Chu2000ErkAP,
  title={Erk and PI-3 kinase are necessary for collagen binding and actin reorganization in corneal epithelia.},
  author={Chia Lin Chu and Wende R. Reenstra and Daniel L Orlow and Kathy Kay Hartford Svoboda},
  journal={Investigative ophthalmology & visual science},
  year={2000},
  volume={41 11},
  pages={
          3374-82
        }
}
PURPOSE It was recently shown that phosphatidylinositol-(PI)3 kinase is upregulated in wounded rabbit corneal epithelia. Extracellular signal-regulated kinase (erk)-1 and -2 proteins and PI-3 kinase were activated in embryonic corneal epithelia after 1-hour stimulation by type I collagen. In the current investigation specific inhibitors of PI-3 kinase and mitogen-activated kinase-kinase (MEK-1 kinase) were used to determine the role of these signaling molecules in actin reorganization and… CONTINUE READING