Erk 1 / 2 MAPK and caldesmon differentially regulate podosome dynamics in A 7 r 5 vascular smooth muscle cells

@inproceedings{Gua2007Erk1,
  title={Erk 1 / 2 MAPK and caldesmon differentially regulate podosome dynamics in A 7 r 5 vascular smooth muscle cells},
  author={Zhizhan Gua and Jolanta Kordowskab and Geoffrey L. Williamsc and C.-L. Albert Wangb and Chi-Ming Haia},
  year={2007}
}
Article Chronology: Received 1 September 2006 Revised version received 5 December 2006 Accepted 6 December 2006 Available online 21 December 2006 We tested the hypothesis that the MEK/Erk/caldesmon phosphorylation cascade regulates PKC-mediated podosome dynamics in A7r5 cells. We observed the phosphorylation of MEK, Erk and caldesmon, and their translocation to the podosomes upon phorbol dibutyrate (PDBu) stimulation, together with the nuclear translocation of phospho-MEK and phosphoErk. After… CONTINUE READING

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