Erik von Willebrand.

@article{Berntorp2007ErikVW,
  title={Erik von Willebrand.},
  author={Erik Berntorp},
  journal={Thrombosis research},
  year={2007},
  volume={120 Suppl 1},
  pages={
          S3-4
        }
}
In 1926, Erik von Willebrand, a Finnish physician, published the first manuscript describing a haemorrhagic disorder in people who were living on the Aland islands off the coast of Finland. This disorder is now known by the name of its discoverer. Since this early observation, von Willebrand disease has been extensively studied. Today, we know the structure and function of the von Willebrand factor and much of its molecular biology. With the availability of safe and effective products, the… Expand
9 Citations
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Von Willebrand disease (VWD) is the most common inherited bleeding disorder. It is caused by a deficiency of the von Willebrand factor (VWF), a protein involved in the haemostasis process. VWD is aExpand
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The recent findings on the effects of VWF mutations on the biosynthetic pathway ofwagen Willebrand factor and its storage in WPBs have deepened the understanding ofVWF synthesis, storage, secretion, and function. Expand
Low von Willebrand Factor in Children and Adolescents: A Review.
TLDR
A narrative review summarizes the observations of several studies that have shed light on the pathophysiologic mechanisms of low VWF and bleeding in patients and the available diagnostic modalities and treatment options and concludes that primary care physicians play an important role in guiding patients with this recently recognized clinicopathologic entity toward appropriate specialty care. Expand
Genetic Modifiers of Hemostasis.
TLDR
In vitro studies suggest that FV can also serve as a cofactor for APC in the inactivation of Factor VIIIa, with FVL demonstrating ten-fold reduced cofactor activity relative to wild type, and in vivo relevance of these two potential mechanisms to the increased thrombosis penetrance associated with FV is addressed. Expand

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