Ergot alkaloids: Hepatic distribution and estimation of absorption by measurement of total radioactivity in bile and urine

@article{Nimmerfall2005ErgotAH,
  title={Ergot alkaloids: Hepatic distribution and estimation of absorption by measurement of total radioactivity in bile and urine},
  author={F. Nimmerfall and Joachim Rosenthaler},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={2005},
  volume={4},
  pages={57-66}
}
  • F. Nimmerfall, Joachim Rosenthaler
  • Published 2005
  • Chemistry, Medicine
  • Journal of Pharmacokinetics and Biopharmaceutics
  • The extent of availability is a measure of the amount of unchanged drug which reaches the systemic circulation following an oral dose. However, absorption as discussed in this communication has the generally accepted meaning of a measure of the disappearance of drug from the gastrointestinal tract and the entrance into the systemic circulation, either as unchanged drug or as metabolite. For many substances, e.g., dihydroergocristine, dihydroergotamine, and ergotamine, excretion in the bile is… CONTINUE READING

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