Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis

@inproceedings{Vijayaraj2012ErgIA,
  title={Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis},
  author={Preethi Vijayaraj and Alexandra Le Bras and Nora Mitchell and Maiko Kondo and Saul F Juliao and Meredith Wasserman and David Beeler and Katherine C. Spokes and William C. Aird and Harold Scott Baldwin and P. Oettgen},
  booktitle={Development},
  year={2012}
}
During murine embryogenesis, the Ets factor Erg is highly expressed in endothelial cells of the developing vasculature and in articular chondrocytes of developing bone. We identified seven isoforms for the mouse Erg gene. Four share a common translational start site encoded by exon 3 (Ex3) and are enriched in chondrocytes. The other three have a separate translational start site encoded by Ex4 and are enriched in endothelial cells. Homozygous Erg(ΔEx3/ΔEx3) knockout mice are viable, fertile and… CONTINUE READING

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defects that are non - overlapping with other TGFbeta knockout phenotypes

  • W. Schachterle, A. Rojas, S. M. Xu, B. L. Black
  • 2012
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