Erdosteine enhances airway response to salbutamol in patients with mild-to-moderate COPD.

@article{Negro2008ErdosteineEA,
  title={Erdosteine enhances airway response to salbutamol in patients with mild-to-moderate COPD.},
  author={Roberto Walter Dal Negro and Maria Aparecida Visconti and Fiorenza Trevisan and Stefano Bertacco and Claudio Micheletto and Silvia Tognella},
  journal={Therapeutic advances in respiratory disease},
  year={2008},
  volume={2 5},
  pages={271-7}
}
BACKGROUND Oxidative stress is presumed to impair beta-adenoceptor function and airway patency. Erdosteine (E), a mucomodulatory compound, has shown important antioxidant properties. METHODS The objective was to assess the effect of antioxidant interventions on short-term airway response to salbutamol in non-reversible mild-to-moderate COPD patients. Thirty COPD patients (GOLD class 1-2), current smoker (>or=10 pack/year), randomly received E 300 mg, N-acetylcysteine (NAC) 600 mg, or placebo… CONTINUE READING