Erdosteine: Antitussive and Anti-inflammatory Effects

@article{Negro2007ErdosteineAA,
  title={Erdosteine: Antitussive and Anti-inflammatory Effects},
  author={Roberto W Dal Negro},
  journal={Lung},
  year={2007},
  volume={186},
  pages={70-73}
}
Erdosteine is a multifactorial drug currently used in COPD for its rheologic activity on bronchial secretions and its positive effects on bacterial adhesiveness. Erdosteine produces an active metabolite (Met 1) which was shown to produce antioxidant effects during the respiratory burst of human PMNs, due to the presence of an SH group. The substantial antitussive effects of erdosteine were first documented in clinical trials even though mucolytic agents are regarded as not consistently… CONTINUE READING
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Erdosteine 600mg, but not placebo and NAC 1200mg, restores airway response to inhaled salbutamol 200mcg in COPD

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Clinical effects of pg/ml 7 6 5 4 PLA ERD 0 1 2 3 * 0 4 7 10 day ANOVA; p<0.02 vs plac Fig. 5 Changes of 8-isoprostane levels in blood following erdosteine 600 mg/day and placebo

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Erdosteine 900mg/day leads to substantial changes in blood ROS, e-NO and some chemotactic cytokines in human secretions of current smokers

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