Erbin controls dendritic morphogenesis by regulating localization of delta-catenin.

  title={Erbin controls dendritic morphogenesis by regulating localization of delta-catenin.},
  author={Jyothi Arikkath and Inbal Israely and Yanmei Tao and Lin Mei and Xin Liu and Louis French Reichardt},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={28 28},
The LAP [leucine-rich and postsynaptic density-95/Discs large/zona occludens-1 (PDZ)] protein erbin and delta-catenin, a component of the cadherin-catenin cell adhesion complex, are highly expressed in neurons and associate through PDZ-mediated interaction, but have incompletely characterized neuronal functions. We show that short hairpin RNA-mediated knockdown of erbin and knockdown or genetic ablation of delta-catenin severely impaired dendritic morphogenesis in hippocampal neurons… CONTINUE READING


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