ErbB4 (JM-b/CYT-1)-induced expression and phosphorylation of c-Jun is abrogated by human papillomavirus type 16 E5 protein

  title={ErbB4 (JM-b/CYT-1)-induced expression and phosphorylation of c-Jun is abrogated by human papillomavirus type 16 E5 protein},
  author={S-L Chen and S-T Lin and T C Tsai and W-C Hsiao and Y-P Tsao},
Human papillomavirus type 16 E5 (HPV-16 E5) is a highly hydrophobic membrane protein with weak-transforming activity, which is associated with ErbB4 receptor in HPV-16-infected cervical lesions. Presently, we investigated the transforming mechanisms of E5 involving ErbB4 signaling. Firstly, we report a role for ErbB4 (JM-b/CYT-1) receptor that activates c-jun gene expression and phosphorylating at Ser63 and Ser73 of the c-Jun protein in ligand-independent and Ras-c-jun NH2-terminal kinase… CONTINUE READING


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View 4 Excerpts
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Publications referenced by this paper.
Showing 1-8 of 8 references

J Biol Chem 274: 10249–10258

AJ Adduci, R. Schlegel
Aqeilan RI, Donati V, Palamarchuk A, Trapasso F, Kaou M, • 1999
View 3 Excerpts
Highly Influenced

Cancer Res 65: 6764–6772

Y Pekarsky
Bacus SS, Zelnick CR, Plowman G, Yarden Y. (1994). Am J • 2005

J Biol Chem 280: 24175–24180

AR, W Long
Culouscou JM, Carlton GW, Aruffo A. (1995). J Biol Chem • 2005

Int J Cancer 84: 24–27

M Korc
Graham FL, Smiley J, Russell WC, Nairn R. (1977). J Gen • 1999

J Biol Chem 271: 7620–7629

N Ben-Baruch
Chen SL, Tsao YP, Chen YL, Huang SJ, Chang JL, Wu SF. • 1996

Nature 378: 390–394

Genther Williams SM, Disbrow GL, Schlegel R, Lee D, • 1995
View 1 Excerpt

Science 256: 1205–1210

JW Park
Hsieh CH, Tsao YP, Wang CH, Han CP, Chang JL, Lee JY • 1992

Science 251: 936–939

Holmes WE, Sliwkowski MX, Akita RW, Henzel WJ, Lee J, • 1991
View 1 Excerpt

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