ErbB3 inhibitory surrobodies inhibit tumor cell proliferation in vitro and in vivo.

@article{Foreman2012ErbB3IS,
  title={ErbB3 inhibitory surrobodies inhibit tumor cell proliferation in vitro and in vivo.},
  author={Pamela K. Foreman and Medini Gore and Philip A. Kobel and Li Xu and Helena Yee and Charles Hannum and Hoangdung Ho and Sandra M. Wang and Hieu Vinh Tran and Michael Abel Horowitz and Lawrence Horowitz and Ramesh R. Bhatt},
  journal={Molecular cancer therapeutics},
  year={2012},
  volume={11 7},
  pages={1411-20}
}
ErbB3 is an important regulator of tumorigenesis and is implicated in development of resistance to several currently used oncology drugs. We have identified ErbB3 inhibitors based on a novel biologic scaffold termed a surrobody. Two of these inhibitors appear to work by a previously unrecognized mechanism of action. As a consequence, they not only inhibited cell proliferation and intracellular signaling driven by stimulation with the ErbB3 ligand neuregulin (NRG), but also inhibited signaling… CONTINUE READING
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