ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation.

@article{Shi2010ErbB3HER3ID,
  title={ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation.},
  author={Fumin Shi and Shannon E. Telesco and Yingting Liu and Ravi Radhakrishnan and Mark A Lemmon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 17},
  pages={7692-7}
}
ErbB3/HER3 is one of four members of the human epidermal growth factor receptor (EGFR/HER) or ErbB receptor tyrosine kinase family. ErbB3 binds neuregulins via its extracellular region and signals primarily by heterodimerizing with ErbB2/HER2/Neu. A recently appreciated role for ErbB3 in resistance of tumor cells to EGFR/ErbB2-targeted therapeutics has made it a focus of attention. However, efforts to inactivate ErbB3 therapeutically in parallel with other ErbB receptors are challenging because… CONTINUE READING
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