ErbB2 trafficking and degradation associated with K48 and K63 polyubiquitination.

@article{Marx2010ErbB2TA,
  title={ErbB2 trafficking and degradation associated with K48 and K63 polyubiquitination.},
  author={Corina Marx and Jason M Held and Bradford W. Gibson and Christopher C. Benz},
  journal={Cancer research},
  year={2010},
  volume={70 9},
  pages={3709-17}
}
The overexpressed ErbB2/HER2 receptor is a clinically validated cancer target whose surface localization and internalization mechanisms remain poorly understood. Downregulation of the overexpressed 185-kDa ErbB2 receptor is rapidly (2-6 hours) induced by the HSP90 chaperone inhibitor geldanamycin (GA), whereas its downregulation and lysosomal degradation are more slowly (24 hours) induced by the proteasome inhibitor bortezomib/PS341. In PS341-treated SK-BR-3 cells, overexpressed ErbB2… CONTINUE READING
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