ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells.

@article{Klos2006ErbB2IV,
  title={ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells.},
  author={Kristine S. Klos and Shannon L. Wyszomierski and Meng-hong Sun and Ming Zhen Tan and Xiaoyan Zhou and Ping Li and Wentao Yang and Guosheng Yin and Walter N. Hittelman and Dihua Yu},
  journal={Cancer research},
  year={2006},
  volume={66 4},
  pages={2028-37}
}
ErbB2 overexpression in breast tumors results in increased metastasis and angiogenesis and reduced survival. To study ErbB2 signaling mechanisms in metastasis and angiogenesis, we did a spontaneous metastasis assay using MDA-MB-435 human breast cancer cells stably transfected with constitutively active ErbB2 kinase (V659E), a kinase-dead mutant of ErbB2 (K753M), or vector control (neo). Mice injected with V659E had increased metastasis incidence and tumor microvessel density than mice injected… CONTINUE READING