ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression.

@article{Rafn2012ErbB2drivenBC,
  title={ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression.},
  author={Bo Rafn and Christian Friberg Nielsen and Sofie Hagel Andersen and Piotr Szyniarowski and Elisabeth Corcelle-Termeau and Erkka Valo and Nicole Fehrenbacher and Charlotta Johanne Olsen and Mads Daugaard and Christina Egebjerg and Trine B\ottzauw and Pekka Kohonen and Jesper Nylandsted and Sampsa Hautaniemi and Jos{\'e} Moreira and Marja J{\"a}{\"a}ttel{\"a} and Tuula Kallunki},
  journal={Molecular cell},
  year={2012},
  volume={45 6},
  pages={764-76}
}
Aberrant ErbB2 receptor tyrosine kinase activation in breast cancer is strongly linked to an invasive disease. The molecular basis of ErbB2-driven invasion is largely unknown. We show that cysteine cathepsins B and L are elevated in ErbB2 positive primary human breast cancer and function as effectors of ErbB2-induced invasion in vitro. We identify Cdc42-binding protein kinase beta, extracellular regulated kinase 2, p21-activated protein kinase 4, and protein kinase C alpha as essential… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 16 references

Similar Papers

Loading similar papers…