ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma.

  title={ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma.},
  author={Congcong Zhang and Michael C Burger and Lukas Jennewein and Sabrina Genssler and Kurt Sch{\"o}nfeld and Pia Susan Zeiner and Elke Hattingen and Patrick N Harter and Michel Mittelbronn and Torsten Tonn and Joachim Peter Steinbach and Winfried S. Wels},
  journal={Journal of the National Cancer Institute},
  volume={108 5}
BACKGROUND Glioblastoma (GBM) is the most common and malignant intracranial tumor in adults and currently incurable. To specifically target natural killer (NK) cell activity to GBM, we employed NK-92/5.28.z cells that are continuously expanding human NK cells expressing an ErbB2-specific chimeric antigen receptor (CAR). METHODS ErbB2 expression in 56 primary tumors, four primary cell cultures, and seven established cell lines was assessed by immunohistochemistry and flow cytometry. Cell… CONTINUE READING
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