ErbB receptors: directing key signaling networks throughout life.

  title={ErbB receptors: directing key signaling networks throughout life.},
  author={Thomas Holbro and Nancy E Hynes},
  journal={Annual review of pharmacology and toxicology},
  • T. HolbroN. Hynes
  • Published 16 January 2004
  • Biology
  • Annual review of pharmacology and toxicology
The epidermal growth factor (EGF)-related peptides bind the ErbB receptors, inducing the formation of different homo- and heterodimers. Receptor dimerization promotes activation of the intrinsic kinase, leading to phosphorylation of specific tyrosines located in the ErbB's cytoplasmic region. These phosphorylated residues serve as docking sites for a variety of signaling molecules whose recruitment stimulates intracellular signaling cascades, which ultimately control diverse genetic programs… 

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