ErbB protein modifications are secondary to severe cell membrane alterations induced by elisidepsin treatment.

@article{Vradi2011ErbBPM,
  title={ErbB protein modifications are secondary to severe cell membrane alterations induced by elisidepsin treatment.},
  author={T{\'i}mea V{\'a}radi and J. Roszik and Duarte Lisboa and G. Vereb and J. M. Molina-Guijarro and C. Galmarini and J. Szöllősi and P. Nagy},
  journal={European journal of pharmacology},
  year={2011},
  volume={667 1-3},
  pages={
          91-9
        }
}
Elisidepsin is a marine-derived anti-tumor agent with unique mechanism of action. It has been suggested to induce necrosis associated with severe membrane damage. Since indirect evidence points to the involvement of ErbB receptor tyrosine kinases and lipid rafts in the mechanism of action of elisidepsin, we investigated the effect of the drug on the distribution of ErbB proteins and systematically compared the elisidepsin sensitivity of cell lines overexpressing ErbB receptors. Stable… Expand
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Homo- and Heteroassociations Drive Activation of ErbB3
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