ErbB Expression: The Mouse Inner Ear and Maturation of the Mitogenic Response to Heregulin

@article{Hume2003ErbBE,
  title={
ErbB Expression: The Mouse Inner Ear and Maturation of the Mitogenic Response to Heregulin
},
  author={Clifford R. Hume and Mette Kirkegaard and Elizabeth C. Oesterle},
  journal={Journal of the Association for Research in Otolaryngology},
  year={2003},
  volume={4},
  pages={422-443}
}
In humans, hair cell loss often leads to hearing and balance impairments. Hair cell replacement is vigorous and spontaneous in avians and nonmammalian vertebrates. In mammals, in contrast, it occurs at a very low rate, or not at all, presumably because of a very low level of supporting cell proliferation following injury. Heregulin (HRG), a member of the epidermal growth factor (EGF) family of growth factors, is reported to be a potent mitogen for neonatal rat vestibular sensory epithelium, but… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 26 CITATIONS

Evaluation of Lapatinib and Trastuzumab for Ototoxic Effects.

  • The journal of international advanced otology
  • 2015
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

In vivo proliferative regeneration of balance hair cells in newborn mice.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2012
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Hair cell replacement in adult mouse utricles after targeted ablation of hair cells with diphtheria toxin.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2012
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 94 REFERENCES

derived factor enhances supporting cell proliferation in both primary epithelium culture and cell line from rodent vestibular organ

R GU, JB YANG, E MAGAL
  • Soc . Neurosci . Abs .
  • 1998
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Induction of cell proliferation in mammalian inner-ear sensory epithelia by transforming growth factor alpha and epidermal growth factor.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1995
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Transforming Growth Factor-α with Insulin Induces Proliferation in Rat Utricular Extrasensory Epithelia

  • Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 1998
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL