ErbB-3 expression is associated with E-cadherin and their coexpression restores response to gefitinib in non-small-cell lung cancer (NSCLC).

@article{Witta2009ErbB3EI,
  title={ErbB-3 expression is associated with E-cadherin and their coexpression restores response to gefitinib in non-small-cell lung cancer (NSCLC).},
  author={Samir E. Witta and Rafal Dziadziuszko and Kazuo Yoshida and Karla J Hedman and Marileila Varella-Garcia and Paul A. Bunn and Fred R Hirsch},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2009},
  volume={20 4},
  pages={689-95}
}
BACKGROUND Epidermal growth factor receptor (EGFR) inhibitors are effective in a subset of patients with non-small-cell lung cancer (NSCLC). We previously showed that E-cadherin expression associates with gefitinib activity. Here, we correlated the expressions of ErbB-3 and E-cadherin in NSCLC tumors and cell lines, their effect on response to gefitinib, and induction of both by the histone deacetylase (HDAC) inhibitors vorinostat and SNDX-275. METHODS Real-time RT-PCR was carried out on RNA… CONTINUE READING
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