ErbB-2 via PYK2 upregulates the adhesive ability of androgen receptor-positive human prostate cancer cells

@article{Yuan2007ErbB2VP,
  title={ErbB-2 via PYK2 upregulates the adhesive ability of androgen receptor-positive human prostate cancer cells},
  author={T-C Yuan and Fei Lin and Suresh Veeramani and Shuxiong Chen and H. Shelton Earp and Mailian Lin},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={7552-7559}
}
Aberrant regulation in the adhesive ability of cancer cells is closely associated with their metastatic activity. In this study, we examine the role of ErbB-2 in regulating the adhesive ability of androgen receptor (AR)-positive human prostate cancer (PCa) cells, the major cell population of PCa. Utilizing different LNCaP and MDA PCa2b cells as model systems, we found that ErbB-2 activity was correlated with PYK2 activity and adhesive ability in those cells. Increased ErbB-2 expression or… CONTINUE READING
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