ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma.

@article{Ammoun2010ErbBHERRA,
  title={ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma.},
  author={Sylwia Ammoun and Clare H. Cunliffe and Jeffrey B. Allen and Luis M. Chiriboga and Filippo G. Giancotti and David Zagzag and Clemens Oliver Hanemann and Matthias A Karajannis},
  journal={Neuro-oncology},
  year={2010},
  volume={12 8},
  pages={834-43}
}
Vestibular schwannomas (VS) arising sporadically or in patients with neurofibromatosis type 2 (NF2) consistently lack expression of Merlin, a tumor suppressor. Conventional treatment options include surgery and radiotherapy but there is no validated medical option. Recent evidence suggests that Merlin deficiency may result in abnormal activation of receptor tyrosine kinases (RTKs) and downstream signaling, promoting tumor growth. Although small-molecule RTK inhibitors are widely available for… CONTINUE READING
30 Citations
49 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Similar Papers

Loading similar papers…