Erasure of a spinal memory trace of pain by a brief, high-dose opioid administration.

@article{DrdlaSchutting2012ErasureOA,
  title={Erasure of a spinal memory trace of pain by a brief, high-dose opioid administration.},
  author={Ruth Drdla-Schutting and Justus Benrath and Gabriele Wunderbaldinger and J{\"u}rgen Sandk{\"u}hler},
  journal={Science},
  year={2012},
  volume={335 6065},
  pages={235-8}
}
Painful stimuli activate nociceptive C fibers and induce synaptic long-term potentiation (LTP) at their spinal terminals. LTP at C-fiber synapses represents a cellular model for pain amplification (hyperalgesia) and for a memory trace of pain. μ-Opioid receptor agonists exert a powerful but reversible depression at C-fiber synapses that renders the continuous application of low opioid doses the gold standard in pain therapy. We discovered that brief application of a high opioid dose reversed… CONTINUE READING
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  • C. Heinl, R. Drdla-Schutting, D. N. Xanthos, J. Sandkühler
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