Erasing Sensorimotor Memories via PKMζ Inhibition

  title={Erasing Sensorimotor Memories via PKMζ Inhibition},
  author={Lee Michael von Kraus and Todd Charlton Sacktor and Joseph T. Francis},
  booktitle={PloS one},
Sensorimotor cortex has a role in procedural learning. Previous studies suggested that this learning is subserved by long-term potentiation (LTP), which is in turn maintained by the persistently active kinase, protein kinase Mzeta (PKMzeta). Whereas the role of PKMzeta in animal models of declarative knowledge is established, its effect on procedural knowledge is not well understood. Here we show that PKMzeta inhibition, via injection of zeta inhibitory peptide (ZIP) into the rat sensorimotor… CONTINUE READING


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