Eradication of tumors from a human colon cancer cell line and from ovarian cancer metastases in immunodeficient mice by a single-chain Ep-CAM-/CD3-bispecific antibody construct.

@article{Schlereth2005EradicationOT,
  title={Eradication of tumors from a human colon cancer cell line and from ovarian cancer metastases in immunodeficient mice by a single-chain Ep-CAM-/CD3-bispecific antibody construct.},
  author={Bernd Schlereth and Iduna Fichtner and Grit Lorenczewski and Petra Kleindienst and Klaus Brischwein and A Marques Joppert Da Silva and Peter Kufer and Ralf Lutterbuese and Ilse Junghahn and Sabine Kasimir-Bauer and Pauline Wimberger and Rainer Kimmig and Patrick A. Baeuerle},
  journal={Cancer research},
  year={2005},
  volume={65 7},
  pages={2882-9}
}
Bispecific T-cell engager (BiTE) are a class of bispecific single-chain antibodies that can very effectively redirect cytotoxic T cells for killing of tumor target cells. Here, we have assessed the in vivo efficacy of one representative, called bscEp-CAMxCD3, with specificity for tumors overexpressing epithelial cell adhesion molecule (Ep-CAM) in human xenograft models. Cells of the human colon carcinoma line SW480 were mixed at a 1:1 ratio with unstimulated human peripheral mononuclear cells… CONTINUE READING

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