Eradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach.

Abstract

Intratumoral injections of a replication-incompetent adenovirus (Ad) expressing melanoma differentiation-associated gene-7/interleukin-24 (Ad.mda-7), a secreted cytokine displaying cancer-selective, apoptosis-inducing properties, profoundly inhibits prostate cancer (PC) growth in immune-incompetent animals. In contrast, Ad.mda-7 is ineffective in PCs… (More)
DOI: 10.1038/mt.2009.252

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@article{Greco2010EradicationOT, title={Eradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach.}, author={Adelaide Greco and Altomare Di Benedetto and Candace M. Howard and Sarah Dion Kelly and Rounak Nande and Yulia Dementieva and Michele Miranda and Arturo Brunetti and Marco Salvatore and Luigi Claudio and Devanand Sarkar and Paul C Dent and David Curiel and P. Brian Fisher and Pier Paolo Claudio}, journal={Molecular therapy : the journal of the American Society of Gene Therapy}, year={2010}, volume={18 2}, pages={295-306} }