Eradication of polymerase chain reaction-detectable chronic lymphocytic leukemia cells is associated with improved outcome after bone marrow transplantation.

@article{Provan1996EradicationOP,
  title={Eradication of polymerase chain reaction-detectable chronic lymphocytic leukemia cells is associated with improved outcome after bone marrow transplantation.},
  author={Drew Provan and Lini Bartlett-Pandite and Caroline Zwicky and Donna S Neuberg and Alison Maddocks and P. Poggi – Corradini and Robert J. Soiffer and Jerome Ritz and Lee M. Nadler and John G Gribben},
  journal={Blood},
  year={1996},
  volume={88 6},
  pages={2228-35}
}
In chronic lymphocytic leukemia (CLL), clonal rearrangement of the immunoglobulin heavy chain locus (IgH) provides a useful marker for the detection of minimal residual disease (MRD) after treatment. At the time of initial presentation, DNA from patients with CLL was polymerase chain reaction (PCR)-amplified using consensus Variable (VH) and Joining (JH) region primers using complementarity determining region III consensus region primers or a panel of VH family-specific framework region 1 (FR1… CONTINUE READING

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