Eradication of breast cancer xenografts by hyperthermic suicide gene therapy under the control of the heat shock protein promoter.

@article{Braiden2000EradicationOB,
  title={Eradication of breast cancer xenografts by hyperthermic suicide gene therapy under the control of the heat shock protein promoter.},
  author={Vera Braiden and Akira Ohtsuru and Yujo Kawashita and Fumio Miki and Tetsuji Sawada and Masataka Ito and Ying-lin Cao and Yasufumi Kaneda and Takehiko Koji and Soichi Yamashita},
  journal={Human gene therapy},
  year={2000},
  volume={11 18},
  pages={2453-63}
}
To investigate the usefulness of heat shock protein (HSP) promoter for breast cancer gene therapy, hyperthermia and HSV thymidine kinase (tk) suicide gene combination therapy was examined with mouse mammary cancer cell line FM3A. HSP promoter activity was markedly increased after heat shock (41-45 degrees C), with maximum activation (about 400-fold) at 3 hr. An in vitro cytotoxic assay showed that HSP-tk-transduced FM3A cells became more sensitive (more than 50,000 times) to ganciclovir (GCV… CONTINUE READING
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