Eradication of biofilm-forming Staphylococcus epidermidis (RP62A) by a combination of sodium salicylate and vancomycin.

@article{Polonio2001EradicationOB,
  title={Eradication of biofilm-forming Staphylococcus epidermidis (RP62A) by a combination of sodium salicylate and vancomycin.},
  author={Roberto Polonio and Leonard A Mermel and Gilbert Paquette and Jay F Sperry},
  journal={Antimicrobial agents and chemotherapy},
  year={2001},
  volume={45 11},
  pages={3262-6}
}
Staphylococcus epidermidis is a major cause of infections associated with indwelling medical devices. Biofilm production is an important virulence attribute in the pathogenesis of device-related infections. Therefore, elimination of these biofilms is an ideal treatment. Salicylate (5 mM) combined with 1 microg of vancomycin per ml inhibited biofilm formation by S. epidermidis (RP62A) by >or=99.9%. When biofilm-coated polystyrene beads were exposed to 5 mM sodium salicylate and 4 microg of… CONTINUE READING

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