Eradication of Myc-overexpressing small cell lung cancer cells transfected with herpes simplex virus thymidine kinase gene containing Myc-Max response elements.

@article{Kumagai1996EradicationOM,
  title={Eradication of Myc-overexpressing small cell lung cancer cells transfected with herpes simplex virus thymidine kinase gene containing Myc-Max response elements.},
  author={Toru Kumagai and Yoshiro Tanio and Tadashi Osaki and Shigeto Hosoe and Isao Tachibana and Koji Ueno and Takashi Kijima and Takeshi Horai and Toshimitsu Kishimoto},
  journal={Cancer research},
  year={1996},
  volume={56 2},
  pages={354-8}
}
Herpes simplex virus thymidine kinase (HSV-TK) gene was ligated with four repeats of the Myc-Max response elements (a core nucleotide sequence CACGTG), and its utility for gene therapy was examined by the treatment of either c-, L- or N-myc-overexpressing the small cell lung cancer (SCLC) cell line with ganciclovir (GCV). The chloramphenicol acetyltransferase assay demonstrated that the overexpression of any myc genes activated transcription from the CAT gene depending on the Myc-Max binding… CONTINUE READING

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