Eradication of B-ALL using chimeric antigen receptor-expressing T cells targeting the TSLPR oncoprotein.

@article{Qin2015EradicationOB,
  title={Eradication of B-ALL using chimeric antigen receptor-expressing T cells targeting the TSLPR oncoprotein.},
  author={Haiying Qin and Monica Cho and Waleed M. Haso and Ling Zhang and Sarah K Tasian and Htoo Zarni Oo and Gian Luca Negri and Yongshun Lin and Jizhong Zou and Barbara S. Mallon and Shannon L Maude and David Teachey and David M Barrett and Rimas J. Orentas and Mads Daugaard and Poul H. B. Sorensen and Stephan A. Grupp and Terry J Fry},
  journal={Blood},
  year={2015},
  volume={126 5},
  pages={629-39}
}
Adoptive transfer of T cells genetically modified to express chimeric antigen receptors (CARs) targeting the CD19 B cell-associated protein have demonstrated potent activity against relapsed/refractory B-lineage acute lymphoblastic leukemia (B-ALL). Not all patients respond, and CD19-negative relapses have been observed. Overexpression of the thymic stromal lymphopoietin receptor (TSLPR; encoded by CRLF2) occurs in a subset of adults and children with B-ALL and confers a high risk of relapse… CONTINUE READING
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