Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta.

@article{Muthyala2004EquolAN,
  title={Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta.},
  author={Rajeev S Muthyala and Young Ho Ju and Shubin Sheng and L. David Williams and Daniel R. Doerge and Benita S Katzenellenbogen and William G Helferich and John A. Katzenellenbogen},
  journal={Bioorganic & medicinal chemistry},
  year={2004},
  volume={12 6},
  pages={1559-67}
}
Equol is a metabolite produced in vivo from the soy phytoestrogen daidzein by the action of gut microflora. It is known to be estrogenic, so human exposure to equol could have significant biological effects. Equol is a chiral molecule that can exist as the enantiomers R-equol and S-equol. To study the biological activity of racemic (+/-)-equol, as well as that of its pure enantiomers, we developed an efficient and convenient method to prepare (+/-)-equol from available isoflavanoid precursors… CONTINUE READING
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