Equivocal p16 immunostaining in squamous cell carcinoma of the head and neck: staining patterns are suggestive of HPV status.

@article{Chen2012EquivocalPI,
  title={Equivocal p16 immunostaining in squamous cell carcinoma of the head and neck: staining patterns are suggestive of HPV status.},
  author={Zhongchuan Will Chen and Ilan Weinreb and Suzanne Kamel-Reid and Bayardo Perez-Ord{\'o}{\~n}ez},
  journal={Head and neck pathology},
  year={2012},
  volume={6 4},
  pages={
          422-9
        }
}
p16 immunohistochemistry (IHC) is commonly used as a surrogate marker for human papillomavirus (HPV) detection in squamous cell carcinomas of the head and neck (SCCHN). However, the HPV status of tumors not staining strongly for p16 is difficult to interpret and may require the use of PCR, not available in all laboratories, as a final arbiter. We aim to determine if staining pattern in equivocal p16 staining and correlation to the percentage of positively stained tumor cells is predictive of… CONTINUE READING
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