Equivalent stimulation of naive and memory CD8 T cells by DNA vaccination: a dendritic cell-dependent process.

@article{Bedoui2009EquivalentSO,
  title={Equivalent stimulation of naive and memory CD8 T cells by DNA vaccination: a dendritic cell-dependent process.},
  author={Sammy Bedoui and Gayle M Davey and Andrew M. Lew and William R Heath},
  journal={Immunology and cell biology},
  year={2009},
  volume={87 3},
  pages={
          255-9
        }
}
CD8 T-cell priming following DNA vaccination has been shown to confer protection against infections and tumors. These vaccines, however, have been disappointing in their ability to boost memory responses in prime-boost settings. We recently found that migratory dendritic cell (DC) subsets inefficiently stimulate memory CD8 T cells, raising the possibility that the poor boosting capacity of DNA encoded antigens might relate to their presentation by subsets of DCs that are only capable of… CONTINUE READING