Equivalent pharmacokinetics of mycophenolate mofetil in African-American and Caucasian male and female stable renal allograft recipients.

@article{Pescovitz2003EquivalentPO,
  title={Equivalent pharmacokinetics of mycophenolate mofetil in African-American and Caucasian male and female stable renal allograft recipients.},
  author={Mark D. Pescovitz and A. Guasch and Robert S. Gaston and Priyanka Rajagopalan and Stephen L. Tomlanovich and Samuel S. Weinstein and Ginny L. Bumgardner and Leonard L. Melton and Patricia Sanwald Ducray and Ludger Banken and Joanna L.O. Hall and Bruno X. Boutouyrie},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2003},
  volume={3 12},
  pages={
          1581-6
        }
}
African-American (AA) renal transplant recipients require higher doses of mycophenolate mofetil (MMF) than Caucasians. A hypothesized pharmacokinetic (PK) difference was tested in stable renal transplant recipients. Whole blood was collected before, and 20, 40 and 75 min, and 2, 3, 4, 6, 8 and 12 h after the MMF dose. Mycophenolic acid (MPA) and its glucuronide metabolite (MPAG) were analyzed using HPLC. Analysis of variance was performed for the primary end-points of dose-adjusted PK… CONTINUE READING
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