Equivalent in vivo biological activity of insulin analogues and human insulin despite different in vitro potencies.

@article{Ribel1990EquivalentIV,
  title={Equivalent in vivo biological activity of insulin analogues and human insulin despite different in vitro potencies.},
  author={Ulla Ribel and Philip Hougaard and K Drejer and Anders R. S\orensen},
  journal={Diabetes},
  year={1990},
  volume={39 9},
  pages={1033-9}
}
In vivo biological potency of two human insulin analogues, AspB9,GluB27 insulin and AspB10 insulin with low and high affinity to the insulin receptor, respectively, was assessed by intravenous infusion of equimolar amounts in pigs, with the euglycemic clamp technique. Human insulin and the low- and high-affinity analogues showed equivalent glucose utilization rates in the steady state (mean +/- SE 14.7 +/- 1.4, 12.7 +/- 1.5, and 12.2 +/- 1.2 mg.kg-1.min-1, respectively; n = 7). The… CONTINUE READING

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