Equivalent doses and relative drug potencies for non-genomic glucocorticoid effects: a novel glucocorticoid hierarchy.

@article{Buttgereit1999EquivalentDA,
  title={Equivalent doses and relative drug potencies for non-genomic glucocorticoid effects: a novel glucocorticoid hierarchy.},
  author={Frank Buttgereit and Martin D. Brand and G. R. Burmester},
  journal={Biochemical pharmacology},
  year={1999},
  volume={58 2},
  pages={363-8}
}
Glucocorticoids have three distinct therapeutically relevant effects (genomic, specific nongenomic, and unspecific non-genomic), raising the hypothesis that the relative potencies of non-genomic and genomic effects of glucocorticoids may differ. Therefore, we measured the unspecific non-genomic potencies of five clinically important glucocorticoids and compared them with the classical (genomic) potencies. We studied the immediate glucocorticoid effects on respiration, on protein synthesis, and… CONTINUE READING

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