Equivalent T Cell Epitope Promiscuity in Ecologically Diverse Human Pathogens

  title={Equivalent T Cell Epitope Promiscuity in Ecologically Diverse Human Pathogens},
  author={Kirsten E. Wiens and Harish Swaminathan and R. Copin and Desmond S. Lun and Joel D Ernst},
  booktitle={PloS one},
BACKGROUND The HLA (human leukocyte antigen) molecules that present pathogen-derived epitopes to T cells are highly diverse. Correspondingly, many pathogens such as HIV evolve epitope variants in order to evade immune recognition. In contrast, another persistent human pathogen, Mycobacterium tuberculosis, has highly conserved epitope sequences. This raises the question whether there is also a difference in the ability of these pathogens' epitopes to bind diverse HLA alleles, referred to as an… CONTINUE READING
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