Equivalence testing of salbutamol dry powder inhalers: in vitro impaction results versus in vivo efficacy.

@article{Weda2002EquivalenceTO,
  title={Equivalence testing of salbutamol dry powder inhalers: in vitro impaction results versus in vivo efficacy.},
  author={Marjolein Weda and Pieter Zanen and Anne Haaije de Boer and Doetie Gjaltema and A Ajaoud and Dirk M. Barends and Henderik Willem Frijlink},
  journal={International journal of pharmaceutics},
  year={2002},
  volume={249 1-2},
  pages={247-55}
}
The aim of the study was to evaluate several impactors for in vitro equivalence testing of salbutamol with respect to efficacy and to define in vitro equivalence limits validated with in vivo efficacy data. The four impactors described in Supplement 2000 of the European Pharmacopoeia were used: Glass Impinger (GI), Metal Impinger (MI), Multistage Liquid Impinger (MSLI) and Andersen Cascade Impactor (ACI). Three salbutamol dry powder formulations with different fine particle doses (FPDs) were… CONTINUE READING