Equivalence and interchangeability of narrow therapeutic index drugs in organ transplantation

@inproceedings{Johnston2013EquivalenceAI,
  title={Equivalence and interchangeability of narrow therapeutic index drugs in organ transplantation},
  author={Atholl Johnston},
  booktitle={European journal of hospital pharmacy. Science and practice},
  year={2013}
}
  • Atholl Johnston
  • Published 2013 in
    European journal of hospital pharmacy. Science…
The calcineurin inhibitors (CNIs), ciclosporin and tacrolimus, are the mainstay of immunosuppression in solid organ transplantation. Generic formulations of these drugs are now available. With increasing pressure on healthcare budgets and the consequent need to match health expectations to available resources, substitution with a generic product appears an attractive option to reduce costs. Approval of generic products differs from innovator drugs, and narrow therapeutic index drugs (NTIs… CONTINUE READING

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