Equitoxic Doses of 5-Azacytidine and 5-Aza-2′Deoxycytidine Induce Diverse Immediate and Overlapping Heritable Changes in the Transcriptome

@inproceedings{Qiu2010EquitoxicDO,
  title={Equitoxic Doses of 5-Azacytidine and 5-Aza-2′Deoxycytidine Induce Diverse Immediate and Overlapping Heritable Changes in the Transcriptome},
  author={Xiangning Qiu and Christoffer Hother and Ulrik M. Ralfki{\ae}r and Alexandra S\ogaard and Qian-jin Lu and Christopher T. Workman and Gangning Liang and Peter A. Jones and Kirsten Gr\onb{\ae}k},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND The hypomethylating agent 5-Azacytidine (5-Aza-CR) is the first drug to prolong overall survival in patients with myelodysplastic syndrome (MDS). Surprisingly, the deoxyribonucleoside analog 5-Aza-2'deoxycytidine (5-Aza-CdR) did not have a similar effect on survival in a large clinical trial. Both drugs are thought to exert their effects after incorporation into DNA by covalent binding of DNA methyltransferase (DNMT). While 5-Aza-CdR is incorporated into only DNA, 5-Aza-CR is also… CONTINUE READING

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