Equine telomeres and telomerase in cellular immortalisation and ageing.

@article{Argyle2003EquineTA,
  title={Equine telomeres and telomerase in cellular immortalisation and ageing.},
  author={David John Argyle and Victoria Ellsmore and Elizabeth A Gault and Alison F. Munro and Lubna Nasir},
  journal={Mechanisms of ageing and development},
  year={2003},
  volume={124 6},
  pages={759-64}
}
To determine the role of telomeres in cellular ageing in equids, we analysed telomere lengths in peripheral blood derived DNA samples from a panel of donkeys (Equus asinus) ranging from 2 to 30 years of age. The average telomere lengths ranged from 7 to 21 kbp and a statistically significant inverse correlation between telomere lengths and donor age was demonstrated. Similarly, telomere lengths in primary fibroblasts isolated from a horse (Equus equus) demonstrated telomeric loss with in vitro… CONTINUE READING